The pericentriolar material (PCM) is created through an extensively interacting network of proteins including SPD-5, SPD-2, and PLK-1. Previously, it was not known whether these proteins formed smaller complexes in the cytoplasm before entering the PCM, or if the interactions only occur as the proteins are incorporated into the PCM matrix. This work, led by graduate student Oliver Wueseke and just published in Molecular Biology of the Cell, shows that these PCM components interact only in the context of PCM assembly, and not in the cytoplasm.
Wuekese O, Bunkenborg J, Hein MY, Zinke A, Viscardi V, Woodruff JB, Oegema K, Mann M, Andersen JS, Hyman AA. The C. elegans pericentriolar material components SPD-2 and SPD-5 are monomeric in the cytoplasm prior to incorporation into the PCM matrix. Mol Biol Cell. 2014 Aug 7. pii: mbc.E13-09-0514. [Epub ahead of print] [PubMed]
Our story on Parkinson’s and the glycolytic pathway has been picked up by several newspapers, radio and TV stations in Germany. It’s safe to say the word is out! See the stories by clicking on the links and images below.
The newest paper from our lab (a collaboration with the Kurzchalia group) is out this month in the open access journal Biology Open.
Toyoda Y, Erkut C, Pan-Montojo F, Boland S, Stewart MP, Müller DJ, Wurst W, Hyman AA, Kurzchalia T. Products of the Parkinson’s disease-related glyoxalase DJ-1, D-lactate and glycolate, support mitochondrial membrane potential and neuronal survival. Biol Open. 2014 Jul 25. pii: BIO20149399.
[MPI-CBG Press Release. Article in the Sächsische Zeitung newspaper.]
This work links the metabolic products of the glyoxalase DJ-1 with mitochondrial health during cellular stress. DJ-1 has previously been linked to the onset of Parkinson’s disease, which is associated with mitochondrial decline in dopaminergic neurons. In this paper, we show that the products of DJ-1 enhance the survival of cultured dopaminergic neurons, indicating that they are a potential therapeutic route for treatment or prevention of Parkinson’s disease.
In the latest addition to our “Two Minute Talk” series, postdoc Elisabeth Fischer-Friedrich explains the biophysics of why and how cells become round during mitosis.
Written & narrated by Elisabeth; produced & directed by Lisa Dennison.
Did you miss 2 im Boot? Now’s your chance to see what it was like! Check out this 4-minute video for a glimpse into the fun evening on a historic steamboat with Tony and Prof. Holger Brandes.