Everything you ever wanted to know about our current understanding of cytoplasmic organization by phase separation, from the physics behind it to the consequences for disease, in one comprehensive review:
In new work published this month in Biology Open, Oliver Wueseke, David Zwicker, Jeff Woodruff, and colleagues show that PKL-1 phosphorylation of the centrosome scaffold protein SPD-5 is a key regulatory step which determines centrosome size and density. Importantly, they show that this step is not necessary for proper maintenance or function of the centrosome. Watch their Science Sketches video abstract below, and read the full article online, which is currently featured on the Biology Open home page!
In a collaboration with the group of Frank Jülicher at the MPI-PKS, Shamba Saha and colleagues have discovered that an RNA-competition mechanism is at the heart of correct P granule positioning in C. elegans. P granules are liquid-like compartments that segregate to the posterior end of the one-cell embryo before cell division. Previous work in our lab revealed that P granules dissolved at one end of the embryo and condensed at the other to drive segregation (Brangwynne et al, 2009), but it was not known what regulated this process until now. Read the paper, the MPI-CBG press release, and watch Shamba’s video abstract below!
In 1996, when Tony was a group leader at the EMBL, he wrote an essay for Current Biology entitled “No man is an island” on the importance of long-term collaboration and shared credit in science. The topic is just as relevant today as it was 20 years ago. Maybe it’s time to implement Tony’s two-dimensional system for assigning authorship! Read the full essay here.
We’ve bid a sad farewell to our intrepid intern, Jana Sipkova. Jana worked for a year with postdoc Shamba Saha, and she was a fantastic addition to the lab. She’s now heading back to the UK to finish up her bachelor studies in London. Good luck, Jana! We miss you already.
New work from our postdoc Elisabeth Fischer-Friedrich and colleagues investigates how the mechanical properties of the cell cortex change to prepare cells for division. Their work “provides a characterization of the time-dependent mechanical properties of the mitotic cortex, confirming that it behaves like an active fluid film on longer timescales. Modulation of the properties of this film drives cell morphology and tissue reorganization.”
In a new talk filmed for iBiology.org, Tony makes the case that funding young investigators is critical to encouraging scientific innovation. Tony discusses the European models of EMBL and the ERC as examples of successful way to separate the funding of junior and senior scientists, thereby giving young investigators more freedom to innovate. As evidence for this, a new qualitative study of ERC grant outcomes found that over 70% of completed Starting and Advanced Grant projects made scientific breakthroughs or major scientific advances.
Watch Tony’s talk and find links to more related resources on iBiology.org!
New work from a collaboration between the Mitchison lab and our institute is out now in the journal Cell. Elvan Boke and colleagues propose that the Balbiani body, a non-membrane-bound compartment in vertebrate oocytes, is formed by amyloid-like assembly of proteins containing prion-like domains. The Balbiani body contains RNA, mitochondria, and other organelles needed by the early embryo after fertilization. The amyloid-like assembly of prion-like proteins in the Balbiani body (such as Xvelo in Xenopus) may form a protective compartment to help oocytes function as long-lived germ cells. The authors show that Xvelo forms a stable matrix with amyloid-like properties both in vivo and in vitro and that the association of Xvelo with the Balbiani body is dependent on Xvelo’s prion-like domain. See the graphical abstract below and read the full paper here: Boke et al, Cell 2016.
Congratulations to Elvan, our postdoc Martine Ruer, and the whole team!
Last week we bid farewell to Mahdiye Ijavi, who was working with postdoc Louise Jawerth to study the physical properties of liquid protein droplets. Mahdiye will be starting a PhD in Zurich, Switzerland in the fall, and we all wish her the best of luck. She will be missed!
Mahdiye’s goodbye dinner. From left: Carsten, Lisa, Avinash, Anatol, Bea, Stefan, Louise, Mahdiye, Mark, Jana, Shamba, Jie, Stephen, and Andrés
If you’re in Woods Hole, join Tony, Ron Vale, Jessica Polka, and Daniel Cólon-Ramos for a town hall discussion on preprints in the life sciences @ 4pm in Rowe Auditorium. For more info on this initiative, visit ASAPbio.org.
Tony arrives today at the Woods Hole Marine Biological Laboratory (MBL). He and two of our postdocs, Jeff Woodruff and Richard Wheeler, are there for the Summer Institute. So if you’re also at Woods Hole this summer, keep an eye out for them and say hello!
• July 11, 11:30am: Jeff and Richard will give back-to-back seminars in Lillie 103.
• July 14, 9:00am: Tony will be giving the Albert Szent-Györgyi Endowed Lecture in the Lillie Auditorium.
Here’s a sneak peek behind the scenes at an interview Tony recently did for a new enterprise called “Latest Thinking”, which aims to “make the most up-to-date knowledge accessible and understandable to everyone.” Stay tuned for links to Tony’s video and the Latest Thinking platform when they go public!
Take a look at the Hyman Lab’s trip to Poland last month! We had two and a half days of lively scientific discussions and fun at the beautiful Pałac Brunów in Lwówek Śląski, Poland. Lab members gave chalk talks on the topic of their scientific question and what they hope to achieve in the coming year. This format lent itself to productive, engaging, and interactive discussions about ongoing work in the lab and the direction in which the lab is headed. We also had a great time kayaking down a river and taking an Urbhanize class with Christina!
Thank you to everyone for a great retreat, with a special thanks to Christina and the organizing committee for planning everything so well. We are already looking forward to next year!
According to a ranking published in “Focus” magazine, Dresden is the most women-friendly city in the country! The study takes into account job opportunities, income equality, fun and leisure, and crimes against women and ranks the 77 largest cities in Germany accordingly. Dresden was named #1, scoring high on equality for women and quality of life. Read more and watch a related video at this link (in German).