Congratulations to Sina and Adam for their fellowships!

Sina and Adam received both each an EMBO postdoc fellowship as well as a Marie Curie postdoc fellowship. This is a great success for both of them but as well for the lab. And yes, of course we celebrated it…

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ASAPbio cenference: Transparency, Recognition, and Innovation in Peer Review in the Life Sciences

Tony will be part of the ASAPbio conference on Transparency, Recognition and Innovation in Peer Review in the Life Sciences taking place February 7th to 9th at the HHMI headquarters in Chevy Chase, Maryland. Several aspects of peer review will be discussed in the meeting and importantly, you can follow the conference by live video streaming.

Check out two essays Tony wrote on Peer Feedback and the defence of the Peer review

 

ASAPbio (Accelerating Science and Publication in biology) is a scientist-driven initiative to promote the productive use of preprints in the life sciences.

Board of Directors
Ron Vale (President)
Cynthia Wolberger (Vice President)
James Fraser (Secretary & Treasurer)
Prachee Avasthi
Daniel Colón-Ramos
Tony Hyman
Heather Joseph
Harlan Krumholz
Maria Leptin
Harold Varmus
Dick Wilder (non-voting)

Director
Jessica Polka

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Congratulations to Titus and coworkers for his Science paper

Prions are self-propagating protein aggregates that can be transmitted between cells. The aggregates are associated with human diseases. Indeed, pathological prions cause mad cow disease and in humans Creutzfeldt-Jakob disease. The aggregation of prion-like proteins is also associated with neurodegeneration as in ALS. The regions within prion-like proteins that are responsible for their aggregation were termed prion-like domains. Despite the important role of prion-like domains in human diseases, a physiological function has remained enigmatic…read more

 

Cryo-Electron Microscopy Image of a biomolecular condensate of a Prion Protein

 

 

Reference:

Titus M. Franzmann, Marcus Jahnel, Andrei Pozniakovsky, Julia Mahamid, Alex S. Holehouse, Elisabeth Nüske, Doris Richter, Wolfgang Baumeister, Stephan W. Grill, Rohit V. Pappu, Anthony A. Hyman und Simon Alberti, Phase separation of a yeast prion protein promotes cellular fitness, Science, (359) 5 January 2018.

DOI: 10.1126/science.aao5654

 

 

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Parkinson Broschüre ist jetzt erhältlich

Ein Forscherteam unseres Hauses hat eine bahnbrechende Entdeckung gemacht, nämlich dass die Gen-Produkte D-Laktat und Glykolat positive Effekte auf angegriffene Zellen haben. Genau das ist das Problem bei der Krankheit Parkinson: Nervenzellen sterben ab, wenn ihre Kraftwerke, die Mitochondrien, nicht mehr richtig funktionieren…mehr

soon this brochure will be available in English as well.

 

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ASCB / EMBO meeting 2017

Beginning of December, Tony was as speaker at the doorstep meeting on cell biology of degeneration and repair in the nervous system, as part of the ASCB / EMBO meeting in Philadelphia. On the same meeting Richard and Titus presented their work in a minisymposium on protein folding, misfolding and neurodegeneration. Congratulations to all speakers!

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EMBO Conference: Quantitative Principles in Biology

Tony would like to thank the organizers of the EMBO Conference on Quantitative Principles in Biology for the invitation, and for putting together such a fantastic meeting. 

2 Nov – 4 Nov 2017
EMBL Heidelberg, GermanyEMBO Conference: Quantitative Principles in Biology
A. Aulehla, J. Garcia-Ojalvo, R. Phillips

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New video abstract! Microtubule nucleation through phase separation

Watch our latest video abstract, created by Amayra Hernández-Vega, describing our recent publication in Cell Reports.

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Celebrating Tony’s Schleiden Medal

The lab went out together to celebrate Tony’s big award! It was a great evening, and you can see a few photos below. 

 

 

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Tony in today’s DNN newspaper

The Dresdner Neueste Nachrichten newspaper ran a story today about Tony receiving the Schleiden Medal! You can read the story online here.

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Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase – congratulations to Amayra Hernández-Vega and colleagues on their paper in Cell Reports!

Our latest publication is now out in Cell Reports. In this work, we show that the protein Tau can phase separate into liquid-like droplets in vitro. These droplets can concentrate tubulin, which enables the polymerization of microtubule bundles that deform the droplets into rod-like structures. Read the full paper online (open access full text) and see the graphical and video abstracts below!

 

This work was a collaboration with the labs of Stefan Diez and Simon Alberti and was led by our postdoc Amayra Hernández-Vega. Congratulations to all involved! 

 

Read a story about the work on Alzforum.

This work was selected for the journal cover. The watercolor painting shows the retraction of tau from rod-like microtubule bundles into spherical drops and the simultaneous debundling of microtubules after treatment with heparin. Artwork by Julia Eichhorn.

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