Read our reviews to learn about “Liquid-liquid phase separation in biology”, “Are aberrant phase transitions a driver of cellular aging?”, and “Biomolecular condensates: organizers of cellular biochemistry”

Everything you ever wanted to know about our current understanding of cytoplasmic organization by phase separation, from the physics behind it to the consequences for disease, in one comprehensive review:

Liquid-liquid phase separation in biology.
Hyman AA, Weber CA, Jülicher F.
Annu Rev Cell Dev Biol. 2014 Oct 11;30:39-58.

2016 UPDATE: Also read a new review and perspective by Tony Hyman and Simon Alberti in Bioessays:

Are aberrant phase transitions a driver of cellular aging?
Alberti S, Hyman AA.
Bioessays. 2016 Oct;38(10):959-68. doi: 10.1002/bies.201600042. Epub 2016 Aug 24.

2017 UPDATE: New review in Nature Reviews Molecular Cell Biology!

Biomolecular condensates: organizers of cellular biochemistry. [PDF]
Banani SF, Lee HO, Hyman AA, Rosen MK.
Nat Rev Mol Cell Biol. 2017 Feb 22.

Impact of water in a water-surface

Image credit: Marlon Felippe, Wikimedia Commons

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EMBO Conference: Quantitative Principles in Biology

Tony would like to thank the organizers of the EMBO Conference on Quantitative Principles in Biology for the invitation, and for putting together such a fantastic meeting. 

2 Nov – 4 Nov 2017
EMBL Heidelberg, GermanyEMBO Conference: Quantitative Principles in Biology
A. Aulehla, J. Garcia-Ojalvo, R. Phillips

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New video abstract! Microtubule nucleation through phase separation

Watch our latest video abstract, created by Amayra Hernández-Vega, describing our recent publication in Cell Reports.

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Celebrating Tony’s Schleiden Medal

The lab went out together to celebrate Tony’s big award! It was a great evening, and you can see a few photos below. 

 

 

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Tony in today’s DNN newspaper

The Dresdner Neueste Nachrichten newspaper ran a story today about Tony receiving the Schleiden Medal! You can read the story online here.

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Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase – congratulations to Amayra Hernández-Vega and colleagues on their paper in Cell Reports!

Our latest publication is now out in Cell Reports. In this work, we show that the protein Tau can phase separate into liquid-like droplets in vitro. These droplets can concentrate tubulin, which enables the polymerization of microtubule bundles that deform the droplets into rod-like structures. Read the full paper online (open access full text) and see the graphical and video abstracts below!

 

This work was a collaboration with the labs of Stefan Diez and Simon Alberti and was led by our postdoc Amayra Hernández-Vega. Congratulations to all involved! 

 

Read a story about the work on Alzforum.

This work was selected for the journal cover. The watercolor painting shows the retraction of tau from rod-like microtubule bundles into spherical drops and the simultaneous debundling of microtubules after treatment with heparin. Artwork by Julia Eichhorn.

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Tony receives Schleiden Medal from German National Academy of Sciences Leopoldina

On behalf of the whole Hyman lab, we want to congratulate Tony on this great honor, which recognizes his achievements and outstanding work in the field of cell biology. You can read the press release on the MPI-CBG website, the text of which is also below.


photo by Tristan Vostry

The German National Academy of Sciences Leopoldina presents Anthony Hyman, director at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden with the Schleiden Medal. The scientist receives the award for outstanding scientific work in the field of cell biology. The award ceremony will take place at the festive opening of the Annual Meeting of the Leopoldina in Halle (Saale) on Friday, 22 September 2017. 

 

Prof. Dr. Anthony Hyman (born 1962) is one of the most influential cell biologists of our time. His research focusses on processes of cell division and the cytoskeleton. One major achievement is the functional genome research on embryos of the nematode C. elegans. Hyman carried out the first genome-wide RNA screening with C. elegans, in order to systematically study its genome. He also comprehensively described the cell division in the C. elegans embryo and identified the significant genes involved in this process. These findings fundamentally changed the view on the development of genetic defects.

 

Another aspect of Hyman’s research deals with functional compartments in the cytoplasm which do not have a membrane. They are formed when liquid components separate from other components in the cell. Hyman was able to show which proteins control the formation of such liquid compartments and how this process is reversed, for example by misfolded proteins. In this case, proteins clump and can become the trigger for degenerative diseases such as amyotrophic lateral sclerosis (ALS).

 

Anthony Hyman studied zoology at the University of London. He received his PhD in 1988 from King’s College in Cambridge (UK) and subsequently worked at the University of California in San Francisco (USA). In 1993 he moved to the European Molecular Biology Laboratory (EMBL) in Heidelberg. Since 1998, Anthony Hyman has served as a Director of the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden. Anthony Hyman was awarded the EMBO Gold Medal in 2003 and the Gottfried Wilhelm Leibniz Prize in 2011 for his achievements.

 

The Schleiden Medal is named after the academy member Matthias Jacob Schleiden (1804-1881). The botanist is one of the founders of the cell theory. The medal has been awarded by the Leopoldina since 1955 for outstanding findings in the field of cell biology.

 

Contact:
Caroline Wichmann
Head of the Press and Public Relations Department
Tel.: 0345 472 39 – 800
E-mail: presse@leopoldina.org

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New video abstract! Building synthetic centrosomes.

Watch our latest video abstract, created by Jeff Woodruff, describing our recent publication in Cell. 

 

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Congratulations to Ceciel Jegers, Boehringer Ingelheim Fellowship winner!

Our PhD student Ceciel Jegers has just been awarded a Boehringer Ingelheim Fellowship to pursue her PhD studies on multi-enzyme condensates. Read more here. Way to go, Ceciel!

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Molecular biology: A liquid reservoir for silent chromatin

Tony and our postdoc Adam Klosin have written a Nature “News & Views” about chromatin compaction in liquid droplets based on two articles in the latest issue of Nature (Strom et al & Larson et al). Read the full News & Views piece here.  

Klosin A, Hyman AA. Molecular biology: A liquid reservoir for silent chromatin. Nature (2017). [PDF]

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The Centrosome Is a Selective Condensate that Nucleates Microtubules by Concentrating Tubulin – congratulations to Jeff Woodruff and colleagues on their paper in Cell!

Our latest publication is out now in Cell! In this work, led by Jeff Woodruffwe used defined components to reconstitute a minimal centrosome in vitro that can nucleate microtubule asters.  Our results suggest that the centrosome acts a selective phase that nucleates microtubules by concentrating microtubule polymerases and soluble tubulin.  

 

Read the full paper in Cell, and watch the video abstract below!

 



The centrosome is a selective condensate that nucleates microtubules by concentrating tubulin.

Jeffrey B. Woodruff, Beatriz Ferreira Gomes, Per O. Widlund, Julia Mahamid, Alf Honigmann, Anthony A. Hyman. 

Cell, 2017. 169(6)1066-1077.

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  • Archives


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  • Recent Videos


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