Congratulations to Titus and coworkers for his Science paper

Prions are self-propagating protein aggregates that can be transmitted between cells. The aggregates are associated with human diseases. Indeed, pathological prions cause mad cow disease and in humans Creutzfeldt-Jakob disease. The aggregation of prion-like proteins is also associated with neurodegeneration as in ALS. The regions within prion-like proteins that are responsible for their aggregation were termed prion-like domains. Despite the important role of prion-like domains in human diseases, a physiological function has remained enigmatic…read more

 

Cryo-Electron Microscopy Image of a biomolecular condensate of a Prion Protein

 

 

Reference:

Titus M. Franzmann, Marcus Jahnel, Andrei Pozniakovsky, Julia Mahamid, Alex S. Holehouse, Elisabeth Nüske, Doris Richter, Wolfgang Baumeister, Stephan W. Grill, Rohit V. Pappu, Anthony A. Hyman und Simon Alberti, Phase separation of a yeast prion protein promotes cellular fitness, Science, (359) 5 January 2018.

DOI: 10.1126/science.aao5654

 

 

This entry was posted in Uncategorized. Bookmark the permalink. Comments are closed, but you can leave a trackback: Trackback URL.
  • Archives


  • Selected Essays

















  • Recent Videos


    An interview with Tony about Phase Transitions and Disease


    Phase separation in cell polarity: Saha et al, Cell 2016


    Encouraging Innovation, iBiology.org


    The genetics linking temperature and fertility in worms: Leaver et al, Biology Open 2016


    Cell PaperFlick on Phase Transitions in Disease


    Check out this playlist to watch all the videos in our "Two Minute Talk" Series


    Ways of Growing, a film created for the MitoSys Project


    What is a Discovery?


    Embryonic Development of C.elegans