Our latest publication, in collaboration with Yamuna Krishnan in Chicago, is out today in Science! In this work, we show that ATP can act as a biological hydrotrope, keeping proteins soluble. Hydrotropes are amphiphilic small molecules that solubilize hydrophobic molecules in aqueous solutions. While ATP is most commonly known as the energy source for cells, there […]
Watch the video abstract for Boke et al 2016, “Amyloid-like self-assembly of a cellular compartment,” and see the full post about it on the Science Sketches website!
Watch a video of Tony explaining phase transitions and disease on the new website “Latest Thinking,” which is a video collection of researchers explaining their latest breakthroughs. Be sure to also check out the videos of Tony answering other short questions in the “Beyond” section just below the main video.
In new work published this month in Biology Open, Oliver Wueseke, David Zwicker, Jeff Woodruff, and colleagues show that PKL-1 phosphorylation of the centrosome scaffold protein SPD-5 is a key regulatory step which determines centrosome size and density. Importantly, they show that this step is not necessary for proper maintenance or function of the centrosome. […]
In a collaboration with the group of Frank Jülicher at the MPI-PKS, Shamba Saha and colleagues have discovered that an RNA-competition mechanism is at the heart of correct P granule positioning in C. elegans. P granules are liquid-like compartments that segregate to the posterior end of the one-cell embryo before cell division. Previous work in […]
In a new talk filmed for iBiology.org, Tony makes the case that funding young investigators is critical to encouraging scientific innovation. Tony discusses the European models of EMBL and the ERC as examples of successful way to separate the funding of junior and senior scientists, thereby giving young investigators more freedom to innovate. As evidence for […]
Congratulations to Mark Leaver on his publication in Biology Open, which is open access and available now online! Click here for the full text. And watch Mark’s 2 minute video abstract below! Leaver M, Kienle S, Begasse ML, Sommer RJ, Hyman AA. A locus in Pristionchus pacificus that is responsible for the ability to give rise to fertile offspring at higher […]
Here’s a short, funny clip that was filmed as part of a movie for the birthday celebration and symposium of MPI-CBG Director Eli Knust. If only Eli had let Tony make Biscuit a new group leader when she was the managing director!
Congratulations to Avinash, Kate, and colleagues for their recent publication in Cell! This work, a close collaboration between our lab and Simon Alberti’s lab, focuses on a protein called FUS, which is implicated in ALS (also known as Lou Gehrig’s disease). By using in vitro and in vivo studies, they show that FUS normally forms liquid compartments. However, when these compartments are “aged” in vitro, they […]
The latest addition to our “Two Minute Talk” series is also our very first video abstract for a Hyman Lab publication (Begasse et al, 2015). Check it out below! And don’t miss Mark’s Two Minute Talk for more information on the current follow-up work in the lab related to Maria’s paper. Written and narrated by […]
iBio video about P granule formation
An interview with Tony about Phase Transitions and Disease
Phase separation in cell polarity: Saha et al, Cell 2016
Encouraging Innovation, iBiology.org
The genetics linking temperature and fertility in worms: Leaver et al, Biology Open 2016
Cell PaperFlick on Phase Transitions in Disease
Check out this playlist to watch all the videos in our "Two Minute Talk" Series
Ways of Growing, a film created for the MitoSys Project
What is a Discovery?
Embryonic Development of C.elegans