Category Archives: Uncategorized

Tony wins Carl Zeiss lecture award

The award to Tony comes from the German Society for Cell Biology for excellent achievements in research and was established in 1990 by the company Zeiss. Tony will lecture on September 27th in Tübingen during the fall conference of the German Society for Biochemistry and Molecular Biology (GBM) and the German Society for Cell Biology […]

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Small molecules that dissolve stress granules

In ALS, a mutated nuclear protein, FUS (fused in sarcoma), mislocalises to the cytoplasm and aggregates in stress granules. This leads to a liquid to solid transition of the granules and a consequent degeneration of the motor neuron (motor neuron die-back ). We show that lipoamide and lipoic acid can prevent the aggregation of FUS and consequently […]

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Suzanne Eaton

We, past and current members of the Hyman lab, are reeling from the sudden and tragic loss of Suzanne Eaton. She was a wonderful person who lives on in our hearts. In this difficult time, we stand together with her family and colleagues. https://www.mpi-cbg.de/suzanne-eaton/

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FlexiBAC, our open source protein expression system

One of great things here at the MPI-CBG are our Service and Facilities, among them the protein expression facility (PEPC), which has been heavily used by us in recent years. In collaboration with Jeff Woodruff, a former postdoc, they developed FlexiBAC, an amazingly versatile protein expression system in insect cells, which was developed with a […]

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We held the first EMBO phase separation course here at the MPI-CBG

From 4th to 13th February we taught our first EMBO course Methods for Studying Phase Separation in Biology here in Dresden at the MPI-CBG and CSBD. The course was organized together with the Tang and Alberti lab, including morning lectures, theoretical or experimental parts during the day and a relaxing evening part. Importantly, we included […]

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Phase separation buffers noise in cells

We are excited to share our pre-print which explores how phase separation affects noise in cells. The question of how cells manage to tightly control protein concentrations has been a long-standing challenge in biology. In collaboration with the Zechner and Jülicher groups, we now show in theory and experiments that liquid-liquid phase separation (LLPS) can […]

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Rheology of protein condensates using optical traps

An increasing number of proteins with intrinsically disordered domains have been shown to phase separate in buffer to form liquidlike phases. These protein condensates serve as simple models for the investigation of the more complex membraneless organelles in cells. To understand the function of such proteins in cells, the material properties of the condensates they […]

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How do you choose a research topic?

Choosing a research topic is an important decision at any level. The choice shapes decisions about what graduate lab to join, which post-doctoral position to pursue, how to start an independent lab, and what companies might make good employers. The thing to remember is that “the choice” can, and perhaps should, be made many times […]

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Phase Transitions form Virus Replication Compartments in Cells

Zoltan’s paper is out! Former postdoc Zoltan worked with the Whelan lab on VSV (Vesicular Stomatitis Virus). RNA viruses like VSV compartmentalize their replication machinery to evade detection by the host. However, it has been unclear how the virus can concentrate the machinery for RNA synthesis. Now it is shown that the replication compartments have […]

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Former postdoc Richard opens his own lab in Oxford

Congratulations to Richard! Check out his website

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  • Selected Videos


    iBio video about P granule formation


    An interview with Tony about Phase Transitions and Disease


    Phase separation in cell polarity: Saha et al, Cell 2016


    Encouraging Innovation, iBiology.org


    The genetics linking temperature and fertility in worms: Leaver et al, Biology Open 2016


    Cell PaperFlick on Phase Transitions in Disease


    Check out this playlist to watch all the videos in our "Two Minute Talk" Series


    Ways of Growing, a film created for the MitoSys Project


    What is a Discovery?


    Embryonic Development of C.elegans