Category Archives: Publication

New publication: Growth and division of active droplets provides a model for protocells

The latest work in our ongoing collaboration with the lab of Frank Jülicher is now out in Nature Physics. Congratulations to all the authors! Growth and division of active droplets provides a model for protocells David Zwicker, Rabea Seyboldt, Christoph A. Weber, Anthony A. Hyman & Frank Jülicher, Nature Physics (2016) Abstract It has been […]

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New preprint: The centrosome is a selective phase that nucleates microtubules by concentrating tubulin

The Hyman lab is proud to publish preprints, which we post in parallel to journal submission. You can find our latest manuscript on bioRxiv, and we welcome your feedback: The centrosome is a selective phase that nucleates microtubules by concentrating tubulin Jeffrey B Woodruff, Beatriz Ferreira Gomes, Per O Widlund, Julia Mahamid, and Anthony A Hyman

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On Research Funding and the Power of Youth

Read the full essay on the importance of funding young scientists, written for the President’s Column of the October issue of the ASCB newsletter by Tony Hyman, Ashad Desai, and Peter Walter. “On Research Funding and the Power of Youth” – PDF

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Congratulations to Oliver, Jeff, and colleagues on their paper & video abstract in Biology Open, investigating regulation of centrosome assembly

In new work published this month in Biology Open, Oliver Wueseke, David Zwicker, Jeff Woodruff, and colleagues show that PKL-1 phosphorylation of the centrosome scaffold protein SPD-5 is a key regulatory step which determines centrosome size and density. Importantly, they show that this step is not necessary for proper maintenance or function of the centrosome. […]

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Read our reviews to learn about “Liquid-liquid phase separation in biology”, “Are aberrant phase transitions a driver of cellular aging?”, and “Biomolecular condensates: organizers of cellular biochemistry”

Everything you ever wanted to know about our current understanding of cytoplasmic organization by phase separation, from the physics behind it to the consequences for disease, in one comprehensive review: Liquid-liquid phase separation in biology. Hyman AA, Weber CA, Jülicher F. Annu Rev Cell Dev Biol. 2014 Oct 11;30:39-58. 2016 UPDATE: Also read a new review […]

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Congratulations to Shamba on his paper in Cell on the positioning of liquid-like compartments through an RNA competition mechanism. Plus – video abstract!

In a collaboration with the group of Frank Jülicher at the MPI-PKS, Shamba Saha and colleagues have discovered that an RNA-competition mechanism is at the heart of correct P granule positioning in C. elegans. P granules are liquid-like compartments that segregate to the posterior end of the one-cell embryo before cell division. Previous work in […]

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“No man is an island”: an essay from the archives about the value of collaboration

In 1996, when Tony was a group leader at the EMBL, he wrote an essay for Current Biology entitled “No man is an island” on the importance of long-term collaboration and shared credit in science. The topic is just as relevant today as it was 20 years ago. Maybe it’s time to implement Tony’s two-dimensional […]

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An interview with Tony in “Lab Times”, news magazine for the European Life Sciences

Read Tony’s interview with Lab Times, in which he discusses peer review, gender equality, open access, and more.

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Congratulations to Elisabeth on her paper “Rheology of the Active Cell Cortex in Mitosis”, out now in Biophysical Journal

New work from our postdoc Elisabeth Fischer-Friedrich and colleagues investigates how the mechanical properties of the cell cortex change to prepare cells for division. Their work “provides a characterization of the time-dependent mechanical properties of the mitotic cortex, confirming that it behaves like an active fluid film on longer timescales. Modulation of the properties of […]

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Congratulations to Elvan, Martine, and colleagues on their paper, “Amyloid-like Self-Assembly of a Cellular Compartment,” out now in Cell

New work from a collaboration between the Mitchison lab and our institute is out now in the journal Cell. Elvan Boke and colleagues propose that the Balbiani body, a non-membrane-bound compartment in vertebrate oocytes, is formed by amyloid-like assembly of proteins containing prion-like domains. The Balbiani body contains RNA, mitochondria, and other organelles needed by […]

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  • Recent Videos


    An interview with Tony about Phase Transitions and Disease


    Phase separation in cell polarity: Saha et al, Cell 2016


    Encouraging Innovation, iBiology.org


    The genetics linking temperature and fertility in worms: Leaver et al, Biology Open 2016


    Cell PaperFlick on Phase Transitions in Disease


    Check out this playlist to watch all the videos in our "Two Minute Talk" Series


    Ways of Growing, a film created for the MitoSys Project


    What is a Discovery?


    Embryonic Development of C.elegans

  • News Archive