Category Archives: Publication

Congratulations to Stephanie for her successful collaboration with the Zerial lab!

Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondria. Hsu F, Spannl S, Ferguson C, Hyman AA, Parton RG, Zerial M. Elife. 2018 Feb 22;7. pii: e32282. doi: 10.7554/eLife.32282   Mitochondrial stress response is essential for cell survival, and damaged mitochondria are a hallmark of neurodegenerative diseases. Thus, it is fundamental to understand how mitochondria […]

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The Centrosome Is a Selective Condensate that Nucleates Microtubules by Concentrating Tubulin – congratulations to Jeff Woodruff and colleagues on their paper in Cell!

Our latest publication is out now in Cell! In this work, led by Jeff Woodruff, we used defined components to reconstitute a minimal centrosome in vitro that can nucleate microtubule asters.  Our results suggest that the centrosome acts a selective phase that nucleates microtubules by concentrating microtubule polymerases and soluble tubulin.     Read the full paper in Cell, and watch the video abstract […]

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Stem cells: the new “model organism”

In a new perspective published in Molecular Biology of the Cell, Tony Hyman and David Drubin “argue that combined advances in genome editing, stem cell production, and organoid derivation from stem cells represent a revolution in cell biology.”  These technological advances mean that stem cell studies could now replace molecular and cell biology studies traditionally […]

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PNAS Journal Club, ACS Spotlights, & Press for “ATP as a biological hydrotrope”

Our article “ATP as a biological hydrotrope” is featured this month as a Journal Club highlight in PNAS!  Additionally, ACS Chemical Biology covered the article in its Spotlights section. It has also been featured in the following news articles and press releases: • Chemical & Engineering News • MPI-CBG Press Release (also in German) • C2W […]

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Two preprints: Tau phase separation; Parallel temperature adaptation

The Hyman lab is proud to publish preprints, which we post in parallel to journal submission. You can find our latest manuscripts on bioRxiv, and we welcome your feedback: Local Nucleation Of Microtubule Bundles Through Tubulin Concentration Into A Condensed Tau Phase. Amayra Hernández-Vega, Marcus Braun, Lara Scharrel, Marcus Jahnel, Susanne Wegmann, Bradley T. Hyman, Simon […]

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An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function

New work from the Hyman and Alberti labs uncovers an important role for chaperone proteins in preventing aberrant phase transitions in stress granules. See a brief synopsis below and read the full paper online. Congratulations to all of the authors on this work! Synopsis The presence of misfolded protein in stress granules alters their dynamic state […]

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ATP as a biological hydrotrope — congratulations to Avinash, Liliana, and colleagues on their paper in Science, in collaboration with Yamuna Krishnan from UChicago!

Our latest publication, in collaboration with Yamuna Krishnan in Chicago, is out today in Science! In this work, we show that ATP can act as a biological hydrotrope, keeping proteins soluble. Hydrotropes are amphiphilic small molecules that solubilize hydrophobic molecules in aqueous solutions. While ATP is most commonly known as the energy source for cells, there […]

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New Review: “Biomolecular condensates: organizers of cellular biochemistry”

Congratulations to our postdoc Kate Lee, Tony, and co-authors Salman Banani and Mike Rosen of UTSW on their new review, “Biomolecular condensates: organizers of cellular biochemistry.” Read the full article using the links below. Biomolecular condensates: organizers of cellular biochemistry. [PDF] Banani SF, Lee HO, Hyman AA, Rosen MK. Nat Rev Mol Cell Biol. 2017 Feb 22. Biomolecular […]

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How did life begin? Dividing droplets could hold the answer. (Article in Quanta Magazine)

The story of our publication in Nature Physics, “Growth and division of active droplets provides a model for protocells,” has been picked up by Quanta Magazine (and re-published in Wired Magazine as well). Read the full story here! 

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Cover of Trends in Molecular Medicine

Belated congratulations are in order to the authors and illustrators of the cover article for the September issue of Trends in Molecular Medicine! See the cover and associated description below. Common molecular pathways in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Jochen H. Weishaupt, Tony Hyman, Ivan Dikic. Trends in Molecular Medicine, 2016. [PDF][PubMed] “Amyotrophic lateral […]

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  • News Archive