Author Archives: Carsten

How do you choose a research topic?

Choosing a research topic is an important decision at any level. The choice shapes decisions about what graduate lab to join, which post-doctoral position to pursue, how to start an independent lab, and what companies might make good employers. The thing to remember is that “the choice” can, and perhaps should, be made many times […]

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Phase Transitions form Virus Replication Compartments in Cells

Zoltan’s paper is out! Former postdoc Zoltan worked with the Whelan lab on VSV (Vesicular Stomatitis Virus). RNA viruses like VSV compartmentalize their replication machinery to evade detection by the host. However, it has been unclear how the virus can concentrate the machinery for RNA synthesis. Now it is shown that the replication compartments have […]

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Former postdoc Richard opens his own lab in Oxford

Congratulations to Richard! Check out his website

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We are organizing an EMBO Practical Course for studying phase separation in biology!

The course takes place 05 – 13 February 2019 in Dresden at the MPI-CBG, register until 1st Oct. 2018, we are looking forward to seeing you here!   #EMBOphaseseparation / facebook   About the Practical Course The field of cell biology is in the midst of a revolution in the understanding of how cells are […]

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Jie’s paper on the molecular grammar of phase separation is out!

Our latest publication is out now in Cell! Congratulations to Jie and all the co-workers.   In this work, Jie Wang and colleagues worked with a family of prion like proteins (FUS family proteins) and suggest rules that define their phase separation behavior. In cells, FUS family proteins can phase separate into liquid like organelles. However, […]

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Check out our new user’s guide for phase separation assays with purified proteins!

Highlights Membrane-less organelles form by phase separation Membrane-less organelles can be reconstituted from minimal components Phase-separating proteins are difficult to purify and handle We provide guidelines and protocols for working with phase-separating proteins   The formation of membrane-less organelles and compartments by protein phase separation is an important way in which cells organize their cytoplasm […]

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Buffering disease: How the nucleus keeps proteins in check

High RNA concentration maintains RNA-binding proteins in solution and prevents pathological aggregates       Many age-related diseases affect the nervous system. One prominent example of a neurodegenerative disease is Amyotrophic Lateral Sclerosis (ALS). The brain tissue of ALS patients typically shows aggregates of so-called prion-like RNA-binding proteins. In the nucleus, these RNA-binding proteins are […]

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Richard’s review on controlling non-membrane-bound organelles is out

Richard stayed in the lab just about a year but his contributions to the Science of the Hyman lab, not forgetting his many social contributions, have been quite big! Now he wrote a review with Tony for the Philosophical Transactions B on controlling non-membrane-bound organelles. They discuss energetically favourable interactions that could drive condensation, and […]

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Edgar is giving a talk at the CSHL meeting Protein Homeostasis in Health and Disease

The Cold Spring Harbor meeting on Protein Homeostasis is taking place from April 17th-21th and Edgar will speak about how Molecular chaperones control the physical state of membrane-less compartments. Go Edgar!

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Congratulations to Stephanie for her successful collaboration with the Zerial lab!

Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondria. Hsu F, Spannl S, Ferguson C, Hyman AA, Parton RG, Zerial M. Elife. 2018 Feb 22;7. pii: e32282. doi: 10.7554/eLife.32282   Mitochondrial stress response is essential for cell survival, and damaged mitochondria are a hallmark of neurodegenerative diseases. Thus, it is fundamental to understand how mitochondria […]

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