Author Archives: Carsten

Jie’s paper on the molecular grammar of phase separation is out!

Our latest publication is out now in Cell! Congratulations to Jie and all the co-workers.   In this work, Jie Wang and colleagues worked with a family of prion like proteins (FUS family proteins) and suggest rules that define their phase separation behavior. In cells, FUS family proteins can phase separate into liquid like organelles. However, […]

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Check out our new user’s guide for phase separation assays with purified proteins!

Highlights Membrane-less organelles form by phase separation Membrane-less organelles can be reconstituted from minimal components Phase-separating proteins are difficult to purify and handle We provide guidelines and protocols for working with phase-separating proteins   The formation of membrane-less organelles and compartments by protein phase separation is an important way in which cells organize their cytoplasm […]

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Buffering disease: How the nucleus keeps proteins in check

High RNA concentration maintains RNA-binding proteins in solution and prevents pathological aggregates       Many age-related diseases affect the nervous system. One prominent example of a neurodegenerative disease is Amyotrophic Lateral Sclerosis (ALS). The brain tissue of ALS patients typically shows aggregates of so-called prion-like RNA-binding proteins. In the nucleus, these RNA-binding proteins are […]

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Richard’s review on controlling non-membrane-bound organelles is out

Richard stayed in the lab just about a year but his contributions to the Science of the Hyman lab, not forgetting his many social contributions, have been quite big! Now he wrote a review with Tony for the Philosophical Transactions B on controlling non-membrane-bound organelles. They discuss energetically favourable interactions that could drive condensation, and […]

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Edgar is giving a talk at the CSHL meeting Protein Homeostasis in Health and Disease

The Cold Spring Harbor meeting on Protein Homeostasis is taking place from April 17th-21th and Edgar will speak about how Molecular chaperones control the physical state of membrane-less compartments. Go Edgar!

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Congratulations to Stephanie for her successful collaboration with the Zerial lab!

Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondria. Hsu F, Spannl S, Ferguson C, Hyman AA, Parton RG, Zerial M. Elife. 2018 Feb 22;7. pii: e32282. doi: 10.7554/eLife.32282   Mitochondrial stress response is essential for cell survival, and damaged mitochondria are a hallmark of neurodegenerative diseases. Thus, it is fundamental to understand how mitochondria […]

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Congratulations to Sina and Adam for their fellowships!

Sina and Adam received both each an EMBO postdoc fellowship as well as a Marie Curie postdoc fellowship. This is a great success for both of them but as well for the lab. And yes, of course we celebrated it…

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Congratulations to Titus and coworkers for his Science paper

Prions are self-propagating protein aggregates that can be transmitted between cells. The aggregates are associated with human diseases. Indeed, pathological prions cause mad cow disease and in humans Creutzfeldt-Jakob disease. The aggregation of prion-like proteins is also associated with neurodegeneration as in ALS. The regions within prion-like proteins that are responsible for their aggregation were […]

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Parkinson Broschüre ist jetzt erhältlich

Ein Forscherteam unseres Hauses hat eine bahnbrechende Entdeckung gemacht, nämlich dass die Gen-Produkte D-Laktat und Glykolat positive Effekte auf angegriffene Zellen haben. Genau das ist das Problem bei der Krankheit Parkinson: Nervenzellen sterben ab, wenn ihre Kraftwerke, die Mitochondrien, nicht mehr richtig funktionieren…mehr soon this brochure will be available in English as well.  

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ASCB / EMBO meeting 2017

Beginning of December, Tony was as speaker at the doorstep meeting on cell biology of degeneration and repair in the nervous system, as part of the ASCB / EMBO meeting in Philadelphia. On the same meeting Richard and Titus presented their work in a minisymposium on protein folding, misfolding and neurodegeneration. Congratulations to all speakers!

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