Read our reviews to learn about “Liquid-liquid phase separation in biology”, “Are aberrant phase transitions a driver of cellular aging?”, and “Biomolecular condensates: organizers of cellular biochemistry”

Everything you ever wanted to know about our current understanding of cytoplasmic organization by phase separation, from the physics behind it to the consequences for disease, in one comprehensive review:

Liquid-liquid phase separation in biology.
Hyman AA, Weber CA, Jülicher F.
Annu Rev Cell Dev Biol. 2014 Oct 11;30:39-58.

2016 UPDATE: Also read a new review and perspective by Tony Hyman and Simon Alberti in Bioessays:

Are aberrant phase transitions a driver of cellular aging?
Alberti S, Hyman AA.
Bioessays. 2016 Oct;38(10):959-68. doi: 10.1002/bies.201600042. Epub 2016 Aug 24.

2017 UPDATE: New review in Nature Reviews Molecular Cell Biology!

Biomolecular condensates: organizers of cellular biochemistry. [PDF]
Banani SF, Lee HO, Hyman AA, Rosen MK.
Nat Rev Mol Cell Biol. 2017 Feb 22.

Impact of water in a water-surface

Image credit: Marlon Felippe, Wikimedia Commons

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Edgar is giving a talk at the CSHL meeting Protein Homeostasis in Health and Disease

The Cold Spring Harbor meeting on Protein Homeostasis is taking place from April 17th-21th and Edgar will speak about how Molecular chaperones control the physical state of membrane-less compartments. Go Edgar!

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Congratulations to Stephanie for her successful collaboration with the Zerial lab!

Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondria.

Hsu F, Spannl S, Ferguson C, Hyman AA, Parton RG, Zerial M.

Elife. 2018 Feb 22;7. pii: e32282. doi: 10.7554/eLife.32282

 

Mitochondrial stress response is essential for cell survival, and damaged mitochondria are a hallmark of neurodegenerative diseases. Thus, it is fundamental to understand how mitochondria relay information within the cell. Here, by investigating mitochondrial-endosomal contact sites we made the surprising observation that the small GTPase Rab5 translocates from early endosomes to mitochondria upon oxidative stress. This process is reversible and accompanied by an increase in Rab5-positive endosomes in contact with mitochondria. Interestingly, activation of Rab5 on mitochondria depends on the Rab5-GEF ALS2/Alsin, encoded by a gene mutated in amyotrophic lateral sclerosis (ALS). Alsin-deficient human induced pluripotent stem cell-derived spinal motor neurons are defective in relocating Rab5 to mitochondria and display increased susceptibility to oxidative stress. These findings define a novel pathway whereby Alsin catalyzes the assembly of the Rab5 endocytic machinery on mitochondria. Defects in stress-sensing by endosomes could be crucial for mitochondrial quality control during the onset of ALS.

 

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Congratulations to Sina and Adam for their fellowships!

Sina and Adam received both each an EMBO postdoc fellowship as well as a Marie Curie postdoc fellowship. This is a great success for both of them but as well for the lab. And yes, of course we celebrated it…

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ASAPbio cenference: Transparency, Recognition, and Innovation in Peer Review in the Life Sciences

Tony will be part of the ASAPbio conference on Transparency, Recognition and Innovation in Peer Review in the Life Sciences taking place February 7th to 9th at the HHMI headquarters in Chevy Chase, Maryland. Several aspects of peer review will be discussed in the meeting and importantly, you can follow the conference by live video streaming.

Check out two essays Tony wrote on Peer Feedback and the defence of the Peer review

 

ASAPbio (Accelerating Science and Publication in biology) is a scientist-driven initiative to promote the productive use of preprints in the life sciences.

Board of Directors
Ron Vale (President)
Cynthia Wolberger (Vice President)
James Fraser (Secretary & Treasurer)
Prachee Avasthi
Daniel Colón-Ramos
Tony Hyman
Heather Joseph
Harlan Krumholz
Maria Leptin
Harold Varmus
Dick Wilder (non-voting)

Director
Jessica Polka

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Congratulations to Titus and coworkers for his Science paper

Prions are self-propagating protein aggregates that can be transmitted between cells. The aggregates are associated with human diseases. Indeed, pathological prions cause mad cow disease and in humans Creutzfeldt-Jakob disease. The aggregation of prion-like proteins is also associated with neurodegeneration as in ALS. The regions within prion-like proteins that are responsible for their aggregation were termed prion-like domains. Despite the important role of prion-like domains in human diseases, a physiological function has remained enigmatic…read more

 

Cryo-Electron Microscopy Image of a biomolecular condensate of a Prion Protein

 

 

Reference:

Titus M. Franzmann, Marcus Jahnel, Andrei Pozniakovsky, Julia Mahamid, Alex S. Holehouse, Elisabeth Nüske, Doris Richter, Wolfgang Baumeister, Stephan W. Grill, Rohit V. Pappu, Anthony A. Hyman und Simon Alberti, Phase separation of a yeast prion protein promotes cellular fitness, Science, (359) 5 January 2018.

DOI: 10.1126/science.aao5654

 

 

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Parkinson Broschüre ist jetzt erhältlich

Ein Forscherteam unseres Hauses hat eine bahnbrechende Entdeckung gemacht, nämlich dass die Gen-Produkte D-Laktat und Glykolat positive Effekte auf angegriffene Zellen haben. Genau das ist das Problem bei der Krankheit Parkinson: Nervenzellen sterben ab, wenn ihre Kraftwerke, die Mitochondrien, nicht mehr richtig funktionieren…mehr

soon this brochure will be available in English as well.

 

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ASCB / EMBO meeting 2017

Beginning of December, Tony was as speaker at the doorstep meeting on cell biology of degeneration and repair in the nervous system, as part of the ASCB / EMBO meeting in Philadelphia. On the same meeting Richard and Titus presented their work in a minisymposium on protein folding, misfolding and neurodegeneration. Congratulations to all speakers!

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EMBO Conference: Quantitative Principles in Biology

Tony would like to thank the organizers of the EMBO Conference on Quantitative Principles in Biology for the invitation, and for putting together such a fantastic meeting. 

2 Nov – 4 Nov 2017
EMBL Heidelberg, GermanyEMBO Conference: Quantitative Principles in Biology
A. Aulehla, J. Garcia-Ojalvo, R. Phillips

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New video abstract! Microtubule nucleation through phase separation

Watch our latest video abstract, created by Amayra Hernández-Vega, describing our recent publication in Cell Reports.

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Celebrating Tony’s Schleiden Medal

The lab went out together to celebrate Tony’s big award! It was a great evening, and you can see a few photos below. 

 

 

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