Congratulations to Oliver, Jeff, and colleagues on their paper & video abstract in Biology Open, investigating regulation of centrosome assembly

In new work published this month in Biology Open, Oliver Wueseke, David Zwicker, Jeff Woodruff, and colleagues show that PKL-1 phosphorylation of the centrosome scaffold protein SPD-5 is a key regulatory step which determines centrosome size and density. Importantly, they show that this step is not necessary for proper maintenance or function of the centrosome. Watch their Science Sketches video abstract below, and read the full article online, which is currently featured on the Biology Open home page!

Polo-like kinase phosphorylation determines Caenorhabditiselegans centrosome size and density by biasing SPD-5 toward an assembly-competent conformation
Oliver Wueseke*, David Zwicker*, Anne Schwager, Yao Liang Wong, Karen Oegema, Frank Jülicher, Anthony A. Hyman, Jeffrey B. Woodruff
Biology Open 2016 5: 1431-1440; doi: 10.1242/bio.020990

This entry was posted in Publication, Video. Bookmark the permalink. Comments are closed, but you can leave a trackback: Trackback URL.
  • Archives


  • Selected Essays

















  • Recent Videos


    An interview with Tony about Phase Transitions and Disease


    Phase separation in cell polarity: Saha et al, Cell 2016


    Encouraging Innovation, iBiology.org


    The genetics linking temperature and fertility in worms: Leaver et al, Biology Open 2016


    Cell PaperFlick on Phase Transitions in Disease


    Check out this playlist to watch all the videos in our "Two Minute Talk" Series


    Ways of Growing, a film created for the MitoSys Project


    What is a Discovery?


    Embryonic Development of C.elegans