Author Archives: hymanlab

Molecular biology: A liquid reservoir for silent chromatin

Tony and our postdoc Adam Klosin have written a Nature “News & Views” about chromatin compaction in liquid droplets based on two articles in the latest issue of Nature (Strom et al & Larson et al). Read the full News & Views piece here.   Klosin A, Hyman AA. Molecular biology: A liquid reservoir for silent chromatin. Nature […]

Posted in Uncategorized | Comments closed

The Centrosome Is a Selective Condensate that Nucleates Microtubules by Concentrating Tubulin – congratulations to Jeff Woodruff and colleagues on their paper in Cell!

Our latest publication is out now in Cell! In this work, led by Jeff Woodruff, we used defined components to reconstitute a minimal centrosome in vitro that can nucleate microtubule asters.  Our results suggest that the centrosome acts a selective phase that nucleates microtubules by concentrating microtubule polymerases and soluble tubulin.     Read the full paper in Cell, and stay tuned for […]

Posted in Publication | Comments closed

Stem cells: the new “model organism”

In a new perspective published in Molecular Biology of the Cell, Tony Hyman and David Drubin “argue that combined advances in genome editing, stem cell production, and organoid derivation from stem cells represent a revolution in cell biology.”  These technological advances mean that stem cell studies could now replace molecular and cell biology studies traditionally […]

Posted in Publication | Comments closed

PNAS Journal Club, ACS Spotlights, & Press for “ATP as a biological hydrotrope”

Our article “ATP as a biological hydrotrope” is featured this month as a Journal Club highlight in PNAS!  Additionally, ACS Chemical Biology covered the article in its Spotlights section. It has also been featured in the following news articles and press releases: • Chemical & Engineering News • MPI-CBG Press Release (also in German) • C2W […]

Posted in Publication | Comments closed

Two preprints: Tau phase separation; Parallel temperature adaptation

The Hyman lab is proud to publish preprints, which we post in parallel to journal submission. You can find our latest manuscripts on bioRxiv, and we welcome your feedback: Local Nucleation Of Microtubule Bundles Through Tubulin Concentration Into A Condensed Tau Phase. Amayra Hernández-Vega, Marcus Braun, Lara Scharrel, Marcus Jahnel, Susanne Wegmann, Bradley T. Hyman, Simon […]

Posted in Publication | Comments closed

Interview with Kate Lee in ‘Research in Germany’

You can now read an interview with our postdoc Kate Lee in “Research in Germany”, where she discusses her work on phase transitions and neurodegenerative disease, her decision to move to Europe, and what she enjoys most about working at the MPI-CBG. Congrats, Kate!

Posted in lab member news | Comments closed

An aberrant phase transition of stress granules triggered by misfolded protein and prevented by chaperone function

New work from the Hyman and Alberti labs uncovers an important role for chaperone proteins in preventing aberrant phase transitions in stress granules. See a brief synopsis below and read the full paper online. Congratulations to all of the authors on this work! Synopsis The presence of misfolded protein in stress granules alters their dynamic state […]

Posted in Publication | Comments closed

ATP as a biological hydrotrope — congratulations to Avinash, Liliana, and colleagues on their paper in Science, in collaboration with Yamuna Krishnan from UChicago!

Our latest publication, in collaboration with Yamuna Krishnan in Chicago, is out today in Science! In this work, we show that ATP can act as a biological hydrotrope, keeping proteins soluble. Hydrotropes are amphiphilic small molecules that solubilize hydrophobic molecules in aqueous solutions. While ATP is most commonly known as the energy source for cells, there […]

Posted in Publication, Video | Comments closed

Kate Lee selected as L’Oréal-UNESCO For Women in Science International Rising Talent

Congratulations to our phenomenal postdoc, Kate Lee, on this prestigious honor! “Kate Lee, postdoc at the MPI-CBG Hyman Lab, is the first scientist living and working in Germany to be selected as “International Rising Talent”. The L’Oréal-UNESCO For Women in Science International Rising Talents are presented to fifteen promising young women, from each world region […]

Posted in lab member news | Comments closed

Advice for young group leaders

Yesterday, Tony gave the EMBO Keynote Lecture at the Young Investigators’ Meeting in Goa, India. In his lecture, titled “From zoology to physics — how to avoid staying in your comfort zone,” Tony gave advice on how to be a successful young group leader. Below, you can watch another talk he gave on a similar topic […]

Posted in Tony | Comments closed
  • Archives


  • Selected Essays

















  • Recent Videos


    An interview with Tony about Phase Transitions and Disease


    Phase separation in cell polarity: Saha et al, Cell 2016


    Encouraging Innovation, iBiology.org


    The genetics linking temperature and fertility in worms: Leaver et al, Biology Open 2016


    Cell PaperFlick on Phase Transitions in Disease


    Check out this playlist to watch all the videos in our "Two Minute Talk" Series


    Ways of Growing, a film created for the MitoSys Project


    What is a Discovery?


    Embryonic Development of C.elegans